Sleep-disordered respiration is related to an elevated danger of postoperative atrial fibrillation.

A meta-analysis discovered that postoperative atrial fibrillation was related to sleep-disordered inhaling sufferers who underwent cardiac surgical procedure.

Sufferers who’ve undergone coronary heart surgical procedure are at elevated danger of growing postoperative atrial fibrillation (POAF) if they’ve sleep-disordered respiration (SDB), in accordance with a brand new evaluate revealed in . Historical past of Drugs.

POAF is a scientific complication in cardiac surgical procedure, with an incidence fee of roughly 35%. A number of research have examined the doable relationship between SDB and POAF, significantly the connection between POAF and obstructive sleep apnea, and the current evaluate aimed to discover the connection between SDB and POAF utilizing obtainable publications.

The researchers used Scopus, PubMed, Net of Science, EMBASE, Cochrane Central Registry for Managed Trials, Wanfang Knowledge, Weipu Database, and China Nationwide Data Infrastructure to look the literature for articles revealed earlier than August 2022. Knowledge on the affiliation between SDB and POAF in sufferers who underwent cardiac surgical procedure assessed SDB standing earlier than cardiac surgical procedure, and recorded POAF throughout postoperative hospital keep or follow-up. All research had been assessed for danger of bias with the Newcastle-Ottawa scale.

Twenty-four research had been included within the meta-analysis, and included 45,361 contributors with SDB and 615,324 contributors with out SDB. The research had been revealed in 11 nations between 1996 and 2022. 8 research got here from the US, 5 from China, 2 from Sweden and Iran, and 1 every from Brazil, Canada, France, Japan, Turkey, Singapore, and Italy.

The incidence of POAF in sufferers with SDB ranged from 8% to 67% in contrast with 6% to 42% in sufferers with out SDB. Atrial fibrillation was identified by steady electrocardiographic monitoring and electrocardiographic examinations, and the commonest kind of surgical procedure was coronary artery bypass graft (CABG).

A forty five% greater danger of POAF within the SDB group was present in sufferers who underwent elective cardiac surgical procedure (odds ratio, 1.49; 95% CI, 1.30-1.70). A subgroup evaluation utilizing SDB measurement methodology, kind of SDB, research design, and kind of surgical procedure—excluding sufferers with a previous historical past of atrial fibrillation—was carried out. discovered that SDB was outlined by medical units, excluding research with potential research design, historical past of CABG, and prior historical past of atrial fibrillation might have elevated the affiliation between SDB and POAG.

The meta-analysis had some limitations. Solely 24 research had been included, which can not have been adequate to acquire definitive outcomes. Exclusion of unpublished information might bias outcomes. Sufferers had been included based mostly on their SDB post-diagnosis rating and medical document information. And retrospective research had been included, so future investigations and evaluations ought to have stricter inclusion standards.

The researchers concluded that the meta-analysis discovered a major affiliation between SDB and the danger of POAF in sufferers who underwent cardiac surgical procedure.

“Nonetheless, additional research ought to be carried out to validate our findings and set up a complete administration for sufferers with SBD,” the authors concluded.


Chen Z, Zhang R, Hu X, et al. Impact of sleep-disordered respiration on postoperative atrial fibrillation in sufferers present process cardiac surgical procedure: a meta-analysis. Ann Med. Revealed on-line on November 9, 2022. doi:10.1080/07853890.2022.2143555

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